If your dog or cat has been prescribed Librela or Solensia for arthritis pain, you may be wondering how safe these injections are and what side effects to watch for. While many pets experience meaningful pain relief, these medications work by targeting Nerve Growth Factor (NGF) to reduce pain signaling—they do not treat or repair the underlying joint damage. In this guide, we’ll look at how Librela and Solensia work, reported side effects and safety concerns, and holistic alternatives that may help support joint health, mobility, and comfort.
Librela and Solensia can provide meaningful pain relief for some pets, but potential side effects and long-term safety considerations are important to understand. Know the benefits and risks before deciding whether these injections are right for your pet, and consider holistic joint-support options as part of a comprehensive arthritis plan.
Bookmark and visit the Pet Advocare website to learn everything you need to know about Librela and Solensia.
Dr. Josie Beug, DVM is an expert in Librela and Solensia. If you are contemplating allowing your pet to take Librela or Solensia, please make a virtual consult appointment with her.
Librela (for dogs) and Solensia (for cats) are monthly injectable medications used to manage osteoarthritis pain. They are part of a newer class of drugs called monoclonal antibodies, designed to target and block Nerve Growth Factor (NGF), a key signal involved in pain.
By reducing NGF activity, these injections aim to decrease the sensation of pain, which can help improve mobility and comfort in some pets. Unlike traditional pain medications, they do not directly reduce inflammation or repair joint damage, but instead work by altering how pain is perceived.
These medications are typically given once a month by a veterinarian and are often recommended for pets with chronic arthritis, especially when other pain management options have not provided enough relief.
Librela and Solensia work by blocking Nerve Growth Factor (NGF), a protein involved in transmitting pain signals. When NGF is reduced, the brain receives fewer pain signals from the joints, which can make pets feel more comfortable.
However, because this approach focuses on reducing pain signals rather than addressing the underlying joint damage, pets may feel better and become more active even though the joint degeneration is still present.
Librela (for dogs) and Solensia (for cats) can provide meaningful arthritis pain relief for some pets, but there are important safety considerations pet parents should understand before deciding whether these injections are right for their dog or cat. These medications target Nerve Growth Factor (NGF), reducing pain signaling, but they do not repair damaged cartilage or address the underlying joint changes associated with arthritis.
Because a pet may feel more comfortable and become more active while the underlying joint disease remains, appropriate activity, weight management, muscle support, and ongoing joint care are still important. Pain relief should be viewed as one part of an arthritis-management plan rather than a treatment for the joint damage itself.
Questions have also been raised about the broader anti-NGF drug class. Similar NGF-targeting medications studied for osteoarthritis in humans encountered safety concerns, including rapidly progressive osteoarthritis and joint damage in some patients. While human anti-NGF drugs are not the same as Librela or Solensia—and human research cannot automatically be applied to dogs and cats—this history is worth understanding when weighing potential benefits and risks.
Adverse events have also been reported following the use of Librela and Solensia. An adverse-event report does not necessarily prove that the medication caused the reaction, but these reports reinforce the importance of monitoring pets carefully, particularly after starting treatment or receiving subsequent injections.
For pet parents interested in a more holistic approach, arthritis management can also focus on supporting the body as a whole through an appropriate anti-inflammatory diet, maintaining a healthy weight, preserving muscle and mobility, supporting cartilage and joint tissues, and incorporating targeted supplements and complementary therapies when appropriate.
Every pet is different. For some, the pain relief provided by Librela or Solensia may meaningfully improve quality of life. For others, the potential risks or individual health history may lead pet parents and their veterinarians to consider other options. Understanding both the potential benefits and limitations can help you make a more informed decision for your pet.
As the use of Librela and Solensia has increased, greater attention has been placed on their potential side effects and adverse events. Many dogs and cats receive these injections without obvious problems, while others may experience changes following treatment. Because reactions can vary from subtle changes in behavior or mobility to more significant medical concerns, careful monitoring is important—particularly after the first injection and after subsequent doses.
Depending on the medication and the individual pet, reported adverse events have included:
Lethargy, weakness or decreased energy
Changes in mobility or gait, including stiffness, wobbliness or unsteady movement
Loss of coordination (ataxia)
Weakness or paresis, particularly involving the hind limbs
Paralysis in some reported cases
Changes in appetite or decreased appetite
Gastrointestinal upset, including vomiting or diarrhea
Increased thirst or urination
Tremors
Seizures or other neurological changes
Skin or injection-site reactions
Other medical conditions have also been reported in pets following treatment. However, it is important to distinguish between an event occurring after an injection and an event being caused by the medication. Adverse-event reports are an important safety signal, but they do not by themselves establish that Librela or Solensia caused a particular illness or condition.
This distinction is especially important when discussing conditions such as pancreatitis, diabetes, cancer, kidney or liver disease. Pet parents should report any new or worsening health problem to their veterinarian, even when it is unclear whether the medication played a role.
Not every pet will experience side effects, and some changes may initially be easy to overlook. Contact your veterinarian if you notice new or worsening symptoms such as:
Wobbliness, stumbling or difficulty standing
Hind-end weakness
Reluctance to walk, climb stairs or jump
Unusual lethargy or weakness
Changes in appetite, thirst or urination
Loss of bladder control
Tremors or seizures
Significant behavioral changes or unusual anxiety
Keeping a simple record of your pet’s mobility, appetite, energy level, bathroom habits and behavior before and after each injection can make it easier to recognize changes that might otherwise be missed.
Librela and Solensia reduce arthritis pain by targeting Nerve Growth Factor (NGF), but they do not rebuild cartilage or repair existing joint damage. A pet who feels significantly better may naturally become more active, which makes appropriate exercise, weight management, muscle support and ongoing joint care especially important.
For pet parents who are concerned about potential adverse effects or want to take a more comprehensive approach to arthritis, supporting joint structure, maintaining healthy muscle, reducing excess inflammation and addressing nutrition and overall metabolic health can be incorporated into a broader arthritis-management plan.
Every pet responds differently. Some may experience substantial improvement in comfort and quality of life with Librela or Solensia, while others may experience adverse effects or may not be appropriate candidates. Understanding what to watch for and discussing any changes promptly with your veterinarian can help you make more informed decisions about continued treatment.
Veterinarian Josie Beug, DVM has also compiled information about Librela and Solensia, reported adverse events, and resources for pet parents whose animals may have experienced problems following treatment on her Pet Advocare website.
The following recovery protocol is reproduced from Dr. Josie Beug, DVM and reflects her recommendations and wording. It is included here as an educational resource for pet parents seeking additional information after a suspected Librela or Solensia reaction.
Support the Nervous System and NGF replenishment:
● Lion’s Mane mushroom: Brand matters, give as high a dose as the stomach can handle, start at a low dose and work your up.
○ Real Mushrooms Lions Mane with Qrill brand (10% off your order) are my favorite
● Omega-3: One of the best and most bioavailable sources for pets are sardines packed in water. Make sure brands are tested for heavy metals. Adored Beast Potent Sea Oil is also a good option.
● Vitamin E: essential for maintaining neurological structure and function.
● Vitamin D levels:
○ Get a blood test to find out how much to supplement. Most animals are deficient.
○ Plays a role in regulation of NGF and is involved in various neurophysiological processes
○ Mushrooms from the grocery store can be set out in the sun for 30 minutes and they will make Vitamin D. Then, saute them in butter and chop them up into food.
● Magnesium: mackerel, organ meats, spinach, chard, pumpkin seeds.
● Zinc: Oysters, green lipped mussels, grass-fed beef, salmon, sardines, broccoli, eggs.
Support the Whole System:
● The best nutrition possible: whole meats, organs, and veggies, grass-fed and organic if possible. If not possible, whole, fresh foods are still preferred over processed pet food. See our arthritis page for diet recommendations.
The body needs bioavailable nutrients to repair and nourish itself. Processed pet foods (kibble) start out with very low -quality ingredients and add in synthetic vitamin and mineral premixes that tax the body.
○ Dr Judy Morgan has a great book, courses and recipes. It does not have to be difficult!
○ Organ meats are loaded with vitamins and minerals. Green Juju makes a nutrient-dense dog food high in organ meats that is easy to digest for dogs with sensitive stomachs. It can be diluted with bone broth, raw milk (5% off this URL) or water in a blender to be syringe fed.
● Minimize pro-inflammatory foods: highly processed kibble or canned, grains, GMO ingredients. This will help decrease inflammation all over the body, including arthritis.
● Antioxidants + Anti-inflammatories: Solutions Pet Products Turmeric and Ginger (5% off this URL), Green tea, Resveratrol and Adored Beast Phyto Synergy
● Adaptogens: Woof Creek Ashwaghanda (10% off this URL), Rhodiola, Ginkgo, Reishi, Cordyceps, Chaga, Eleuthero,Holy Basil, Animal Essentials Astragalus (10% coupon: SAVINGPETS10), Ginseng, Schisandra, + others.
○ They help the body adjust to stress and help it regain homeostasis and balance.
● Probiotics to heal and maintain a healthy gut
○ 70 % of the immune system is in the gut
● Raw goats milk or raw cows milk: contains live enzymes, probiotics and all the amino acids and nutrients it takes to grow a baby goat into an adult goat.
○ Goat vs cow: fewer allergies and intolerances
○ Like a super food for our pets with readily available nutrients and enzymes
○ Can be syringe fed as a complete meal!
● CBD: use a good reputable brand
○ Can help maintain homeostasis, reduce pain , increase appetite and decrease stress. Helps communication between the nervous system, endocrine system and immune system.
○ It is very safe to use.
○ CBD Dog Health Ease (15% coupon: SAVINGPETS)or Bailey’s CBD for Pets (30% coupon: SAVINGPETS30)
Support Protein Metabolism:
● PROTEASE: the enzyme made by the body to digest proteins (an antibody is a protein circulating in the bloodstream).
○ Make sure it is high quality and used for immunomodulation and proteolytic enzyme therapy.
○ The average protease in a digestive enzyme supplement is not sufficient.
○ Brand I recommend with research behind them is Transformation Enzymes
○ It is safe to use. Start low and work up to what is tolerable.
Support Specific Organs:
● Liver: metabolic and detox pathways:
○ Feeding liver
○ Animal Essentials Dandelion (10% coupon: SAVINGPETS10)
○ All medicinal mushrooms: Turkey tail, Reishi, Chaga
○ Chinese herbs
● Cardiac:
○ Feeding heart(5% OFF THIS URL)
○ RX VITAMINS CoQ10 (10% DISCOUNT WITH THIS URL)
○ FIVE LEAF BOTANICALS Hawthorn (10% DISCOUNT FOR NEW CUSTOMERS): SAVINGPETS)
○ Chinese herbs
● Kidney:
○ Feeding kidney
○ Standard Process Canine Renal Support
○ANIMAL ESSENTIALS Nettle HERBAL TONIC (10% COUPON: SAVINGPETS10)
○ Chinese herbs
● Bladder incontinence: this can have neural, hormonal, infectious (UTI) and stress related causes (cystitis).
○ Incontinence: Chinese herbs available
○ Acupuncture
○ ACCORDING TO GOSPEL Red light therapy
○ Vasopressin if the pituitary is affected – requires blood testing.
Support and Remedies for Arthritis:
● Bone broth: Collagen Type II is a pain reliever
● NSAIDS: Rimadyl, Metacam, Galliprant, Previcox
○ Different dogs respond to different NSAIDS individually.
○ Make sure they are given proper dose, with food – not on an empty stomach
○ Check blood values prior to using and while using to detect problems early.
○ If appetite decreases or any vomiting or diarrhea occur, STOP.
○ It’s easier to detox from a course of NSAIDS than an injection meant to last a
month or more.
● GABAPENTIN: I am not a big fan and there is NO scientific evidence it provides any pain control. It is being prescribed at very high doses which can lead to wobbly gate, spaced out cognitive issues and even breathing difficulties. It is becoming a controlled substance in several states due to street abuse and addiction. Here is my review article on it: Gabapentin for Dogs: Know the Risks
● Glucosamin, chondroitin, collagen: numerous supplements available. Woof Creek Hip and Joint Support for Dogs and Cats (10% off this URL) and Adored Beast Jump for Joynts
● Adequan injections: glycosaminoglycans
● Turmeric: Golden Paste
● Boswellia
○ Ayush Herbs Boswelya Plus Joint Relief for Active Pets can work as well, and in conjunction with an NSAID
● Traumeel/Traulevium: homeopathic anti-inflammatory
● Other homeopathics: these need to be selected on a case by case basis by an
experienced homeopath
● Physical rehab + exercise: Keep them moving to strengthen the muscles.
● Acupuncture:
○ Needs to be done regularly
○ Supports entire body
○ Has been shown to increase NGF and stem cells
● Massage therapy: helps with pain, stiffness, lymphatic drainage, quality of life
● Photobiomodulation: Red Light Therapy + Laser:
○ Use a reliable source, not the cheap version on Amazon
○ I use MultiRadiance lasers. They do have a pet laser for at home use. We recommend Medco Vet Luma
○ I use Photonic Health for red light therapy. Made in the USA, 90 day money back. According to Gospel Red Light Therapy is used by many of the moderators of this website
● Pulsed Electromagnetic Field Therapy: Assisi loop lounge
● Extracorporeal shock wave therapy
● Herbal Medicine: there are numerous Traditional Chinese formulas and western herb formulas that are very efficacious for arthritis pain. To get the best results work with aknowledgeable herbalist to find the right formula for your pet.
Last, but not least, give it time!
**Do NOT use flea/tick preventatives containing isoxazolines: that includes Bravecto, Nexgard,
Simparica. These have all been implicated in neurological symptoms of tremors and seizures.
They have an FDA warning label on the box! See our flea/tick page for other options.
If you have questions, concerns or are looking for further guidance, you can visit my Substack, or schedule a virtual consult on my website. My email, is included but I cannot answer questions about individual cases without a thorough case review and consult.
Librela is an FDA-approved monoclonal antibody designed to block Nerve Growth Factor (NGF), and it is prescribed to help manage osteoarthritis pain in dogs. By targeting NGF, the goal is to reduce the sensation of pain, which can improve mobility and comfort in some pets.
Have NGF-Blocking Drugs Been Studied in Humans?
Medications that target NGF have also been studied extensively in human medicine. Two of the most well-known are tanezumab (developed by Pfizer and Eli Lilly) and fasinumab (developed by Regeneron).
Tanezumab underwent more than a decade of research and over 40 clinical trials, with significant investment behind it. However, it was ultimately not approved for human use after safety concerns were raised, including issues related to joint deterioration. Advisory committees voted against approval, concluding that the potential risks outweighed the benefits. The European Medicines Agency reached a similar conclusion and declined approval as well.
Fasinumab, another anti-NGF therapy, also faced challenges during development. Clinical studies were paused after reports of adverse effects, including concerns related to joint health.
Across multiple studies, NGF inhibitors as a class have been associated with changes in joint integrity in certain cases, which has led to ongoing discussion and caution in both human and veterinary medicine.
So why was Librela approved for dogs?
The approval process for veterinary medications is different from that of human drugs, with different study designs, endpoints, and regulatory thresholds. While Librela has been approved for use in dogs with osteoarthritis pain, many pet parents choose to look more closely at the available research and consider how this class of drugs has performed across both human and animal studies when making decisions.
For those looking to explore this topic further, Dr. Josie Beug, DVM has compiled detailed information on reported side effects and supportive care considerations for affected pets.
Solensia is FDA-approved for managing osteoarthritis pain in cats and is part of a newer class of medications designed to block Nerve Growth Factor (NGF), a key signal involved in pain.
Is there a human equivalent to Solensia?
Yes. Solensia belongs to the same class of anti-NGF drugs that were developed and studied extensively for human use, including tanezumab and fasinumab. These medications underwent years of clinical trials and significant investment in an effort to bring them to market.
What happened in human studies?
In human trials, NGF-blocking drugs were effective at reducing pain. However, researchers also observed concerning outcomes in some patients, including accelerated joint degeneration. In certain cases, this progression was severe enough to require joint replacement. Due to these safety concerns, these drugs were ultimately not approved for human use in the United States, and similar decisions were made by European regulatory agencies.
So why is Solensia approved for cats?
The approval process for veterinary medications differs from that of human drugs, with different study requirements and long-term data expectations. While Solensia has been approved for use in cats with osteoarthritis pain, long-term safety data is still developing, and many effects are monitored after the product is already in use.
Reported side effects in cats include:
The key concern:
Like Librela, Solensia does not repair joint damage. It works by blocking the pain signal, which can make a cat feel more comfortable without improving the underlying condition.
When pain feedback is reduced, a cat may continue to move on already compromised joints. Over time, this can place additional stress on those joints and may contribute to further degeneration in certain cases.
Josie Beug, DVM has done a tremendous job documenting the facts, side effects and how to deal with pets who have been impacted by Librela and Solensia on her Pet Advocare website. Read Dr. Josie’s Beug’s Librela/Solensia Recovery Protocol.
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“Dr. Graham Matherson Introduces Tvati for Pets”.
“Head Trainer and President of Capalaba Race Track ” by John Catton.
If your pet has ever had a reaction after a vaccine, flea or tick product, antibiotic, or medication, your experience matters more than you may realize. Holistic pet parents are often the first to notice subtle changes — digestive upset, behavior shifts, immune flares, neurological signs, or a general sense that something is “off.”
You do not need proof that a product caused the reaction. You do not need permission from a veterinarian. Reporting simply means sharing what you observed so safety patterns can be recognized and other pets can be protected.
Many adverse events go unreported, especially when symptoms are delayed or considered “mild.” When holistic pet parents speak up, those missing pieces finally get documented.
Antibiotics and other medications such as steroids, NSAIDs, seizure medications, GI drugs, and topical treatments are regulated by the FDA through its Center for Veterinary Medicine.
If your pet experienced vomiting, diarrhea, appetite loss, lethargy, anxiety, seizures, skin reactions, organ stress, or if a medication simply did not work as expected, you can report it directly.
The easiest way is through the FDA Safety Reporting Portal for animal drugs and devices. You can also start at the FDA’s animal reporting page, which explains all available options.
If you prefer to speak with someone, you can call 1-888-FDA-VETS (1-888-332-8387).
Another important step is contacting the medication’s manufacturer. Their contact information is listed on the product label or packaging, and they are legally required to forward adverse event reports to the FDA.
Vaccines are regulated differently from medications. Animal vaccines fall under the USDA, not the FDA.
If your pet had a reaction after vaccination — whether it happened immediately or weeks later — it can and should be reported.
You can report vaccine reactions through the USDA Center for Veterinary Biologics. Information and reporting options are available here.
You can also contact the USDA Center for Veterinary Biologics directly at 800-752-6255.
In addition, vaccine manufacturers should be notified. Their information is typically listed on the vaccine label or your pet’s invoice.
From a holistic perspective, it’s important to remember that vaccine reactions are not always dramatic. Digestive changes, autoimmune flare-ups, chronic itching, behavioral changes, or immune suppression that appear later still matter and are worth reporting.
Flea and tick products require special attention because they are regulated in two different ways, depending on the product.
Some flea and tick products, including many oral chewables and prescription topical medications, are regulated as animal drugs by the FDA. Reactions to these products should be reported through the same FDA channels listed above or directly to the manufacturer.
Other flea and tick products, such as many collars, sprays, powders, and some topical insecticides, are regulated as pesticides by the EPA.
If your pet had a reaction to one of these products, you can find reporting instructions here.
You may also contact the National Pesticide Information Center (NPIC) at 1-800-858-7378, where incidents are documented and forwarded to the EPA. When reporting, include the EPA Registration Number found on the product label whenever possible.
A few reminders for holistic pet parents: trust your observations, even if the reaction was delayed. Mild symptoms still count. You can report even if your veterinarian disagrees. Saving labels, packaging, and lot numbers can be very helpful, but they are not required.
Reporting an adverse event is not about blame or fear. It is about awareness, transparency, and advocacy. Many product warnings, label changes, and safety investigations only happen after enough pet parents speak up.
Your voice helps protect pets everywhere.
Dr. Judy Morgan (2025 Holistic Veterinarian of the Decade): “Zoetis Librela: The Latest Information & Update.”
Dr. Judy Morgan (2025 Holistic Veterinarian of the Decade): “Negative Experiences Pets Have Had with Librela – Part 1.”
Dr. Judy Morgan (2025 Holistic Veterinarian of the Decade): “Negative Experiences Pets Have Had with Librela – Part 2 of My Librela Story Time.”
“Zoetis Stock Crumbles After Report Suggest Arthritis Shots Sickening Dogs & Cats” by Allison Gatlin.
“Solensia 💉 Pain Management for Cats with Osteoarthritis ⚠️ Potential Risks & Side Effects” by Dr. Judy Morgan and Josie Beug, DVM.
“What’s The REAL Truth About Librela And Solensia Injections for Pets?” by Dr. Andrew Jones.
“Leading Vet Warns Of ‘Wonder Drug’ Being Used On Pets-After Reports From the U.S. That It Could Be Killing Hundreds Of Pets” by Tom Lawrence.
“Do Your Research: Pet Owner Warns Others After Linking Cats Death to New Arthritis Drug” by WSB-TV2.
We encourage you to join the Librela The Truth (Berensa, Solensia, Leniva, Portela) Facebook Group.
If you have a question on this topic that wasn’t answered here, we invite you to ask it in our Facebook group.
This is what we would do for our pets (do either the Adored Beast Jump for Joynts or Gold Standard Herbs Lumbrex and Voltrex):
Librela is a monoclonal antibody injection designed to block nerve growth factor (NGF) and reduce arthritis pain. While some dogs show improved mobility, there have also been reports of lethargy, neurologic changes, gastrointestinal upset, and worsening weakness. Because it reduces pain signals without repairing the joints, careful monitoring after each injection is important. Many pet parents choose to explore other options that support joint health more directly.
Solensia and Librela work in a similar way but are species-specific. Solensia is approved for cats, while Librela is used in dogs. Both target nerve growth factor (NGF) to reduce pain associated with osteoarthritis. While some pets appear to benefit, concerns have been raised about side effects and long-term impact, leading some pet parents to consider alternative approaches.
A more comprehensive approach to joint health focuses on reducing inflammation and supporting the body over time. This may include a species-appropriate, minimally processed diet, omega-3 fatty acids, green-lipped mussel, collagen support, and maintaining a healthy weight. Supportive therapies such as physical therapy, acupuncture, and targeted supplements can also help improve comfort and mobility while addressing the underlying condition rather than only masking pain.
There is no set timeframe for how long Librela side effects may last. Some reactions may be temporary and improve within days, while others—particularly neurological or mobility-related problems—may persist longer and require veterinary care.
Librela (bedinvetmab) is a long-acting monoclonal antibody given once monthly. In dogs with osteoarthritis, its elimination half-life averages approximately 19 days, although it can vary considerably between dogs. This means the medication does not immediately leave the body if a reaction occurs.
The FDA has received post-approval reports involving problems such as loss of coordination (ataxia), seizures, weakness or paresis, paralysis, increased thirst and urination, urinary incontinence, vomiting, diarrhea, tremors and lethargy. However, adverse-event reports do not necessarily prove that Librela caused the problem, and the FDA does not provide a specific timeframe in which these reactions should resolve.
If your dog develops new weakness, difficulty walking or standing, loss of bladder control, seizures, significant gastrointestinal symptoms, or other concerning changes after a Librela injection, contact your veterinarian promptly rather than waiting for the medication to wear off.
Neurological problems have been reported in some dogs following Librela injections. The FDA lists neurological adverse events reported after Librela use, including loss of coordination (ataxia), seizures, weakness or partial paralysis (paresis), proprioception deficits, and paralysis.
Pet parents should watch for new or worsening signs such as wobbliness, stumbling, difficulty standing or walking, hind-leg weakness, tremors, unusual changes in coordination, or seizures—particularly after starting Librela or following subsequent injections.
It is important to understand that an adverse-event report does not necessarily prove that Librela caused the neurological problem. However, the FDA considered the post-approval reports significant enough to update Librela’s labeling and advise veterinarians to discuss potential adverse events with pet parents before each injection.
Dogs with existing neurological or mobility problems deserve particular consideration. Discuss your dog’s complete medical history with your veterinarian and carefully weigh the potential benefits and risks before starting or continuing treatment. If neurological changes develop after a Librela injection, contact your veterinarian promptly and report the reaction.
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